Hydrogen Bromide → HCID 14579481, compound

HRID 1607734Notes

Reaction equation

HRID 1607734 reaction equation
Cl.[NH2:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12]C)=[CH:8][C:7]=1[F:14])[CH3:5].C(=O)(O)[O-].[Na+].[BrH:20]>C(Cl)(Cl)Cl>[BrH:20].[F:14][C:7]1[CH:8]=[C:9]([OH:12])[CH:10]=[CH:11][C:6]=1[CH:4]([CH3:5])[CH2:3][NH2:2]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 516892Sodium BicarbonateHCID 14579468HCID 14579468, compound

Product 1

HCID 14579481HCID 14579481, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

4.19 g of 1-amino-2-(2-fluoro-4-methoxyphenyl)propane hydrochloride are neutralized with a mixture of chloroform and an aqueous sodium bicarbonate solution. The chloroform layer is separated therefrom and condensed to dryness. Hydrobromic acid is added to the residue, and the mixture is refluxed. Then, the reaction mixture is evaporated, and the residue is recrystallized from a mixture of isopropylalcohol and isopropylether. 4.53 g of 3-fluoro-4-(2-amino-1-methylethyl)phenol hydrobromide are obtained.

Workup

  1. customThe chloroform layer is separated
  2. customcondensed to dryness
  3. temperaturethe mixture is refluxed
  4. customThen, the reaction mixture is evaporated
  5. customthe residue is recrystallized from a mixture of isopropylalcohol and isopropylether

Sources & evidence

ORD record
ord-f7f647a3b02041b793fd3ef7602321a7
Source dataset
uspto-grants-1989_09
Patent number
US04866196

Reaction notes

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