L-Pyroglutamic Acid → N-[Hydroxy(5-hydroxy-3,4-dihydro-2H-pyrrol-2-yl)methylidene]glycine

HRID 1607868Notes

Reaction equation

HRID 1607868 reaction equation
[NH:1]([C:6]([O:8]C(C)(C)C)=O)[CH2:2][C:3]([OH:5])=[O:4].[NH:13]1[C:17](=[O:18])[CH2:16][CH2:15][C@H:14]1C(O)=O>>[NH:13]1[C:17](=[O:18])[CH2:16][CH2:15][C@H:14]1[C:6]([NH:1][CH2:2][C:3]([OH:5])=[O:4])=[O:8]

Participants

3

Reactant 2

HCID 7405L-Pyroglutamic AcidHCID 78288N-(tert-butoxycarbonyl)glycine

Product 1

HCID 152981N-[Hydroxy(5-hydroxy-3,4-dihydro-2H-pyrrol-2-yl)methylidene]glycine

Procedure

2 mmoles of Boc-Gly-Rx were used as starting material, and 0.90 g of pGlu were added according to the usual principles for solid peptide synthesis.

Workup

  1. additionwere added

Sources & evidence

ORD record
ord-f9fdfceba0f24412be332e3a9f318530
Source dataset
uspto-grants-1989_09
Patent number
US04868156

Reaction notes

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