Boron tribromide → 85893-94-3

HRID 1607893Notes

Reaction equation

HRID 1607893 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([O:9]C)[CH:5]=[CH:4][C:3]=1[C:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[S:13][N:12]=1.B(Br)(Br)Br>ClCCCl>[S:13]1[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:11]([C:3]2[CH:4]=[CH:5][C:6]([OH:9])=[C:7]([Cl:8])[C:2]=2[Cl:1])=[N:12]1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 14536452HCID 14536452, compound

Product 1

HCID 13596777585893-94-3Yield 96%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

A mixture containing 8.2 g of 3-(2,3-dichloro-4-methoxyphenyl)benzisothiazole, 100 ml of 1,2-dichloroethane and 100 ml of BBr3 was refluxed for 30 minutes. Itwas then poured into ice/water and the organic solvent was removed under reduced pressure. The product was then filtered off, washed with hexane and dried to give 7.50 g (96%) of 4-(benzisothiazol-3-yl)-2,3-dichlorophenol.

Workup

  1. temperaturewas refluxed for 30 minutes
  2. customthe organic solvent was removed under reduced pressure
  3. filtrationThe product was then filtered off
  4. washwashed with hexane
  5. customdried

Sources & evidence

ORD record
ord-5edaaa91988e4045af5b1a7b7af4ff01
Source dataset
uspto-grants-1989_09
Patent number
US04868188

Reaction notes

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