Hydrochloric Acid → HCID 14438342, compound

Temperature

-78 °C

To a tetrahydrofuran (THF) solution of 5-chloro-1-pentynyllithium prepared from 5-chloro-1-pentyne (5.43 g, 53 mmol) and n-butyllithium (20.4 mL, 53 mmol) cooled to -78° C. was added sec-butyldiisopropoxyborane (8.74, 48 mmol) in 48 mL THF. The reaction mixture was stirred at -78° C. for an additional 1 h, then quenched with hydrogen chloride in ethyl ether (15.5 mL, 53 mmol). The cooling bath was removed and the reaction mixture allowed to warm to room temperature. The lithium chloride was allowed to settle and the clear supernatant was decanted via a double-ended needle into a distillation flask. The remaining solid lithium chloride was washed with THF, 2×15 mL, and added to the distillation flask. Volatiles were removed with reduced pressure, followed by high vacuum distillation. Yield: 9.5 g (92%), bp 72°-74° C. (0.1 mm Hg); n20D 1.4496; proton NMR (CDCl3)δ4.63 (septet, J=18 Hz, 1H), 3.60 (triplet, J=18 Hz, 2H), 2.47 (triplet, J=18 Hz, 2H), 1.17 (d, J=18 Hz, 6H), 0.87 (m, 6H); boron NMR (EE)δ+41.3 ppm (s); mass spectrum (chemical ionization, isobutane), m/e 213 (M+H, 8%). IR (thin film) 2185, 1325 cm-1. Anal. Calcd. for C12H28BClO: C, 63.06; H, 9.70; B, 4.73. Found: C, 63.14; H, 9.60; B, 4.48.

1. customThe cooling bath was removed
2. temperatureto warm to room temperature
3. customthe clear supernatant was decanted via a double-ended needle into a distillation flask
4. washThe remaining solid lithium chloride was washed with THF, 2×15 mL
5. additionadded to the distillation flask
6. customVolatiles were removed with reduced pressure
7. distillationfollowed by high vacuum distillation

ORD record

ord-9a243cce9ff4476498fe12a167fb2a61

Source dataset

uspto-grants-1989_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04868337