反应详情

温度

70 °C

To a stirred solution of 4-acetylamino-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide (4.0 g) in dimethylformamide (20 ml) is N-chlorosuccinimide (1.3 g), and the resulting mixture is stirred at 70° C. for 2 hours. The reaction mixture is poured into ice-water and extracted with diethyl ether. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, dried over magnesium sulfate, and evaporated. The residue is recrystallized from acetone to give the title compound (3.1 g), mp 161°-163° C.

1. extractionextracted with diethyl ether
2. washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
3. dry with materialdried over magnesium sulfate
4. customevaporated
5. customThe residue is recrystallized from acetone