Potassium Iodide → HCID 14882034, compound

HRID 1608221Notes

Reaction equation

HRID 1608221 reaction equation
Cl[CH2:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:11])[CH2:5]1.[C-]#N.[K+].[I-].[K+].[CH3:25][N:26](C)C=O>O>[C:25]([CH2:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:11])[CH2:5]1)#[N:26]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 6228DimethylformamideHCID 9032Potassium CyanideHCID 14882033HCID 14882033, compound

Product 1

HCID 14882034HCID 14882034, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2-(2-chloroethyl)-4-benzyloxycarbonylmorpholine (16 g), potassium cyanide (6.3 g), potassium iodide (1 g), and dimethylformamide (50 ml) is heated at 100° C. with stirring for 5 hours. After cooling, the reaction mixture is diluted with water and extracted with diethyl ether. The organic layer is dried over sodium sulfate and evaporated. The residue is crystallized from diethyl ether-hexane to give the title compound (10.7 g), mp 59°-60° C.

Workup

  1. temperatureAfter cooling
  2. extractionextracted with diethyl ether
  3. dry with materialThe organic layer is dried over sodium sulfate
  4. customevaporated
  5. customThe residue is crystallized from diethyl ether-hexane

Sources & evidence

ORD record
ord-bfb86163dcbd419cb8459ec38ba8efc1
Source dataset
uspto-grants-1989_09
Patent number
US04870074

Reaction notes

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