反应详情

A solution of 5-chlorosulfonyl-2-fluorobenzoic acid (7.0 g) and 28% ammonia water (20 ml) in tetrahydrofuran (70 ml) is stirred at 0° C. for 1.5 hours. The reaction mixture is poured into water (200 ml), acidified with concentrated hydrochloric acid, and extracted with chloroform. The extracts are washed with water, dried over sodium sulfate, and evaporated under reduced pressure. The residue is washed with diethyl ether to give the title compound (5.0 g).

1. extractionextracted with chloroform
2. washThe extracts are washed with water
3. dry with materialdried over sodium sulfate
4. customevaporated under reduced pressure
5. washThe residue is washed with diethyl ether