1-Butanol → 1-benzhydrylazetidine

HRID 1608364Notes

Reaction equation

HRID 1608364 reaction equation
[CH:1]([NH2:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:16][CH2:17][CH2:18]Cl.C(O)CCC.C(=O)([O-])[O-].[K+].[K+]>O>[CH:1]([N:14]1[CH2:18][CH2:17][CH2:16]1)([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 2631-ButanolHCID 7036BenzhydrylamineHCID 80061-Bromo-3-chloropropaneHCID 11430Potassium Carbonate

Product 1

HCID 28028951-benzhydrylazetidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Step 1, heating benzhydrylamine and 1-bromo-3-chloropropane in admixture with butanol, water and potassium carbonate to give N-benzhydrylazetidine and separating said N-benzhydrylazetidine therefrom;

Sources & evidence

ORD record
ord-399bd918c7474f9a8f5d323a015f886b
Source dataset
uspto-grants-1989_09
Patent number
US04870189

Reaction notes

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