Hydrochloric Acid → HCID 178423709, compound

HRID 1608369Notes

Reaction equation

HRID 1608369 reaction equation
C(CC[N:5]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)=[N:8][N:7]=[N:6]1)#N.[OH-].[Na+].C1COCC1.Cl>O>[CH3:22][C:19]1[CH:20]=[CH:21][C:16]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9]2[NH:5][N:6]=[N:7][N:8]=2)=[CH:17][CH:18]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 14425673HCID 14425673, compound

Product 1

HCID 178423709HCID 178423709, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-[1-(β-cyanoethyl)-1-H-tetrazol-5-yl]-4'-methylbiphenyl (689 mg, 2.38 mmol), 1,0N NaOH (2.62 mL, 2.62 mmol) and THF (15 mL) were mixed and stirred at room temperature. After 15 minutes, water (100 mL) was added and the pH adjusted to 3.0 with conc. HCl. The aqueous mixture was extracted with ethyl acetate (3×100 mL) and the organic layers were combined, dried (MgSO4) and evaporated in vacuo to yield 550 mg of a white powder. M.P.=148.5°-150.0°. The spectral data matched those of a sample prepared via Method A.

Workup

  1. extractionThe aqueous mixture was extracted with ethyl acetate (3×100 mL)
  2. dry with materialdried (MgSO4)
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-3512045b889043f5a71772483cc749a5
Source dataset
uspto-grants-1989_09
Patent number
US04870186

Reaction notes

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