反应详情

温度

80 °C

Under a nitrogen atmosphere, p-hydroxythiophenol (126 g) was dissolved in N,N-dimethylformamide (600 ml) and thereto was added potassium carbonate (152 g). Thereto was added octadecyl chloride (318 g), followed by heating at 80° C. for 2 hours. After completion of the reaction, the reaction mixture was poured into water to precipitate a white solid. Thereto was added 5% hydrochloric acid to adjust the pH to acidic state and then, the white solid was filtered off under reduced pressure and then recrystallized from methyl ethyl ketone to obtain the desired product (261 g). Yield 70%; m.p. 95° C.

1. customAfter completion of the reaction
2. customto precipitate a white solid
3. additionThereto was added 5% hydrochloric acid
4. filtrationthe white solid was filtered off under reduced pressure
5. customrecrystallized from methyl ethyl ketone