Hydrochloric Acid → Hydrochloric Acid

HRID 1608695Notes

Reaction equation

HRID 1608695 reaction equation
[ClH:1].[C:2]([CH2:4][CH:5]([CH2:11][S:12]C(=O)C)[CH2:6][S:7][C:8](=[O:10])[CH3:9])#[N:3].CO>O1CCCC1>[C:8]([S:7][CH2:6][CH:5]1[CH2:11][S:12][C:2](=[NH:3])[CH2:4]1)(=[O:10])[CH3:9].[ClH:1]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 20087055HCID 20087055, compound

Product 2

HCID 313Hydrochloric AcidHCID 20087069HCID 20087069, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Gaseous HCl is passed during 0.5 hour through a solution of 3 g of 2-cyanomethyl-1,3-bis(acetylthio)propane, obtained according to Example XIX e), and 1.8 g of methanol in 30 ml tetrahydrofurane; temperature 40°-55° C. The solution is evaporated; diethylether is added to the residue. The precipitate formed is aspirated off, washed with diethylether and dried. The second title compound, viz. 4-acetylthiomethyl-2-iminothiolane is obtained as its HCl sale in a yield of 600 rag; m.p. 186°-188° C. (decomp.). Identification by 1H NMR and 13C NMR. The compound can equally be converted to the free base.

Workup

  1. customobtained
  2. customtemperature 40°-55° C
  3. customThe solution is evaporated
  4. additiondiethylether is added to the residue
  5. customThe precipitate formed
  6. washwashed with diethylether
  7. customdried

Sources & evidence

ORD record
ord-66f54f0403be48d78250edab1265284f
Source dataset
uspto-grants-1995_03
Patent number
US05395946

Reaction notes

Loading…