反应详情

0.4 g of sodium hydride (97% pure), 15 ml of toluene and 15 ml of anhydrous N,N-dimethylformamide were placed in a 100 flask fitted with a magnetic stir bar and water-cooled condensor with a dry nitrogen inlet. Then 3.3 g (0.0106 moles) of 5-decyl-2-(4-hydroxyphenyl)pyrimidine was slowly added. After stirring for 30 minutes at room temperature, 3.9 g (0.0106 moles) of 5-ethoxy-2,2,3,3,4,4-hexafluoropentyl trifluoromethanesulfonate (made essentially as in Example 3) was added and the contents stirred overnight at room temperature. The contents then were poured into a separatory funnel containing 30 ml of water. The funnel was shaken and the two layers formed were allowed to separate. The aqueous layer was extracted twice with two 15 ml aliquots of toluene. The organic layers were combined, then washed four times with 20 ml aliquots of deionized water, dried with anhydrous sodium sulphate, and stripped of solvent using a rotary evaporator. The resulting oil was chromatographed on silica gel (chloroform) to obtain 2.07 g of 5-decyl-2-(4-(5-ethoxy-2,2,3,3,4,4-hexafluoropentoxy)phenyl)pyrimidine.

1. customfitted with a magnetic stir bar
2. additionwas added
3. stirringthe contents stirred overnight at room temperature
4. additionThe contents then were poured into a separatory funnel
5. stirringThe funnel was shaken
6. customthe two layers formed
7. customto separate
8. extractionThe aqueous layer was extracted twice with two 15 ml aliquots of toluene
9. washwashed four times with 20 ml aliquots of deionized water
10. dry with materialdried with anhydrous sodium sulphate
11. customa rotary evaporator
12. customThe resulting oil was chromatographed on silica gel (chloroform)