Potassium Carbonate → HCID 54344046, compound

HRID 1608957Notes

Reaction equation

HRID 1608957 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[CH:5][CH:4]=1.[OH:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[N:14]1[CH:15]=[CH:16][C:11]([CH:10]=[CH:9][C:6]2[CH:7]=[CH:8][C:3]([CH2:2][O:17][C:18]3[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=3)=[CH:4][CH:5]=2)=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 130194-CyanophenolHCID 53664064HCID 53664064, compound

Product 1

HCID 54344046HCID 54344046, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 2.3 g (10 mmol) 4-[2-(4-chloromethylphenyl)-ethenyl]-pyridine, 1.2 g (10 mmol) 4-hydroxybenzonitrile, 1.4 g potassium carbonate and 10 ml butanone is heated under reflux for 18 h, filtered, the filtrate evaporated, taken up in ethyl acetate, washed with water, dried and evaporated. One obtains 2.0 g of title compound (64% of theory) of the m.p. 147°-149° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 18 h
  3. filtrationfiltered
  4. customthe filtrate evaporated
  5. washwashed with water
  6. customdried
  7. customevaporated

Sources & evidence

ORD record
ord-4e737b643d9e4e67af7df72fe2763f67
Source dataset
uspto-grants-1995_03
Patent number
US05399575

Reaction notes

Loading…