Hydrochloric Acid → HCID 178428935, compound

HRID 1609128Notes

Reaction equation

HRID 1609128 reaction equation
C([O:3][C:4]([C:6]1[C:7]([CH3:32])=[N:8][C:9]([CH3:31])=[CH:10][C:11]=1[O:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]2[NH:30][N:29]=[N:28][N:27]=2)=[CH:16][CH:15]=1)=[O:5])C.Cl>[OH-].[Na+]>[C:4]([C:6]1[C:7]([CH3:32])=[N:8][C:9]([CH3:31])=[CH:10][C:11]=1[O:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]2[NH:30][N:29]=[N:28][N:27]=2)=[CH:18][CH:19]=1)([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178470019HCID 178470019, compound

Product 1

HCID 178428935HCID 178428935, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

150 mg of the compound obtained in Example 40 was dissolved in 2 ml of 1N NaOH. The solution was stirred at 60°-70° C. for 24 hours, and then cooled. The pH of the reaction mixture was adjusted to 3 with 1N HCl. The precipitate obtained was collected by filtration, washed with water, and then dried to give 84 mg of a colorless powder of the title compound (yield: 60%).

Workup

  1. temperaturecooled
  2. customThe precipitate obtained
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-12ba4e7e938347c9bad4ef4c16694f9c
Source dataset
uspto-grants-1995_03
Patent number
US05399566

Reaction notes

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