Nitrogen → HCID 178447298, compound

HRID 1609176Notes

Reaction equation

HRID 1609176 reaction equation
C[O:2][C:3](=[O:28])[C@H:4]([CH3:27])[N:5]([C:21](=[O:26])[CH2:22][CH2:23][CH2:24][CH3:25])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]#[N:20])=[CH:9][CH:8]=1.CCCCC(Cl)=O.[N:36]#[N:37].C([N:40](CC)CC)C>>[C:3]([C@@H:4]([N:5]([C:21](=[O:26])[CH2:22][CH2:23][CH2:24][CH3:25])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[NH:20][N:40]=[N:37][N:36]=2)=[CH:9][CH:8]=1)[CH3:27])([OH:2])=[O:28]

Participants

5

Reactant 4

HCID 947Nitrogen2×HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 53687967HCID 53687967, compound

Product 1

HCID 178447298HCID 178447298, compound

Procedure

N-valeryl-N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-alanine methyl ester starting from 1.65 g of N-[(2'-cyanobiphenyl)-methyl]-(L)-alanine methyl ester, 2.7 ml of triethylamine and 2.35 ml of n-valeryl chloride and subsequent flash chromatography (N2). (TLC: system N2) Rf : 0.62.

Sources & evidence

ORD record
ord-fb743e62d8b84921a51a4de85501b46b
Source dataset
uspto-grants-1995_03
Patent number
US05399578

Reaction notes

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