Chloride → [1-(tert-Butyl-dimethyl-silanyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-[1-(4-chloro-phenyl)-ethoxy]-3-methoxy-phenyl-methanol
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([n:6]1[cH:7][c:8]([I:15])[c:9]2[c:10]1[n:11][cH:12][cH:13][cH:14]2)([CH3:16])[CH3:17].[CH:19]([Mg+:20])([CH3:21])[CH3:22].[Cl-:18].[Cl:23][c:24]1[cH:25][cH:26][c:27]([CH:30]([CH3:31])[O:32][c:33]2[c:34]([O:41][CH3:42])[cH:35][c:36]([CH:37]=[O:38])[cH:39][cH:40]2)[cH:28][cH:29]1.[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([n:6]1[cH:7][c:8]([CH:37]([c:36]2[cH:35][c:34]([O:41][CH3:42])[c:33]([O:32][CH:30]([c:27]3[cH:26][cH:25][c:24]([Cl:23])[cH:29][cH:28]3)[CH3:31])[cH:40][cH:39]2)[OH:38])[c:9]2[c:10]1[n:11][cH:12][cH:13][cH:14]2)([CH3:16])[CH3:17]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-d047039016cb4fdc9a73e3a0fdbba676
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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