反应详情

In 10 ml of DMF were suspended 1.1 g of methyl 4-[2-(2-cyanophenylthio)phenylcarbamoyl]phenoxyacetate, 0.85 g of sodium azide and 0.7 g of ammonium chloride, and the mixture was Stirred at 110°-120° C. for 8 hours. After cooling, the reaction mixture was acidified with concentrated hydrochloric acid and diluted with water. The resulting precipitate was subjected to silica gel column chromatography (chloroform→chloroform-ethanol=50:1) to give 0.4 g of the title compound as white crystals, m.p. 204°-205° C.

1. temperatureAfter cooling