Triphenylphosphine → Triphenylphosphine hydrochloride

HRID 1609332Notes

Reaction equation

HRID 1609332 reaction equation
[Cl:1]CC1N=C(C2CCC2)SC=1.[C:12]1([P:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C=CC=CC=1>[Cl-:1].[C:25]1([PH+:18]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 187590944-Chloromethyl-2-cyclobutyl-thiazole

Product 1

HCID 9882740Triphenylphosphine hydrochloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 4.8 g of 4-chloromethyl-2-cyclobutyl-thiazole, 7.0 g of triphenylphosphine and 125 ml of toluene was heated to reflux for 16 hr and then cooled to room temperature. The mixture was then filtered to yield 4.8 g of [(2-cyclobutyl-4-thiazolyl)methyl]=triphenylphosphonium chloride.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 16 hr
  3. filtrationThe mixture was then filtered

Sources & evidence

ORD record
ord-9457bf3dd4c5472484bcc43448dfd73a
Source dataset
uspto-grants-1995_03
Patent number
US05399702

Reaction notes

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