Water → (S)-1-[2-(Acetyloxy)-1-phenylethyl]-2,5-dihydro-1H-pyrrol-2,5-dione

HRID 1609370Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1609370
C[Si](C)(C)NC(N[Si](C)(C)C)=O.[C:13]1([C@@H:19]([CH2:21][OH:22])[NH2:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[C:23]1(=[O:29])[O:28][C:26](=O)[CH:25]=[CH:24]1.O.C1C[O:34][CH2:33][CH2:32]1>>[C:33]([O:22][CH2:21][C@@H:19]([N:20]1[C:23](=[O:29])[CH:24]=[CH:25][C:26]1=[O:28])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:34])[CH3:32]

Komponenten

6

Edukt 5

HCID 962WaterHCID 7923Maleic AnhydrideHCID 8028TetrahydrofuranHCID 875621,3-Bis(trimethylsilyl)ureaHCID 1347972-Amino-2-phenylethan-1-ol

Produkt 1

HCID 9859949(S)-1-[2-(Acetyloxy)-1-phenylethyl]-2,5-dihydro-1H-pyrrol-2,5-dioneAusbeute 83 %

Versuchsvorschrift

1,3-Bis(trimethylsilyl)urea (0.745 g, 3.65 mM) was added to (S)-(+)-2-phenylglycinol (0.5 g, 3.65 mM) dissolved in THF (10 ml, distilled from Na/benzophenone). The mixture was refluxed for 1 hr. A precipitate formed. Maleic anhydride (0.376 g, 3.83 mM) was added and the mixture was refluxed for 0.5 hr. H2O (66 μl, 3.65 mM) was added to the cooled mixture and stirred for 30 min. to form the intermediate ##STR46## which was not recovered from the reaction mixture. Tetrabutyl-ammonium fluoride (TBAF.3H2O, 0.115 g, 0.365 mM), acetic anhydride (Ac2O) (3.44 ml, 36.5 mM), and TEA (3.0 ml, 21.9 mM) were added and the mixture refluxed for 2.5 hrs. After cooling to room temperature, H2O (15 ml) was added and stirred for 1 hr. The reaction mixture was taken up in EtOAc (75 ml), washed with water (2×50 ml), 5% NaHCO3 (50 ml), brine (25 ml), dried (MgSO4), and evaporated to a black oil: 0.88 g. The oil was Kugalrohr distilled under vacuum (~0.3 mm), oven temperature 110°-30°, giving the title compound as a colorless oil: 0.79 g (83% yield). TLC (silica gel, EtOAc/hexane 7:3 visualized with UV and KMnO4) showed the product as one spot at Rf 0.60.

Aufarbeitung

  1. temperatureThe mixture was refluxed for 1 hr
  2. customA precipitate formed
  3. temperaturethe mixture was refluxed for 0.5 hr
  4. customto form the intermediate ##STR46## which
  5. customwas not recovered from the reaction mixture
  6. additionTetrabutyl-ammonium fluoride (TBAF.3H2O, 0.115 g, 0.365 mM), acetic anhydride (Ac2O) (3.44 ml, 36.5 mM), and TEA (3.0 ml, 21.9 mM) were added
  7. temperaturethe mixture refluxed for 2.5 hrs
  8. additionH2O (15 ml) was added
  9. stirringstirred for 1 hr
  10. washwashed with water (2×50 ml), 5% NaHCO3 (50 ml), brine (25 ml)
  11. dry with materialdried (MgSO4)
  12. customevaporated to a black oil
  13. distillationdistilled under vacuum (~0.3 mm), oven temperature 110°-30°

Quellen und Nachweise

ORD-Eintrag
ord-171dc289a9b442c38ad5cf0ad52d7d9b
Quelldatensatz
uspto-grants-1995_03
Patentnummer
US05399725

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