Methylamine → HCID 22814771, compound

HRID 1609412Notes

Reaction equation

HRID 1609412 reaction equation
[CH2:1]([OH:12])[C@H:2]1[O:8][C:6](=[O:7])[C@H:5]([OH:9])[C@@H:4]([OH:10])[C@@H:3]1[OH:11].[CH3:13][NH2:14]>C(O)(C)C.CO>[CH3:13][NH:14][C:6]([C@@H:5]([C@H:4]([C@@H:3]([C@@H:2]([CH2:1][OH:12])[OH:8])[OH:11])[OH:10])[OH:9])=[O:7]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 7027delta-Gluconolactone

Product 1

HCID 22814771HCID 22814771, compound

Reagents, catalysts & solvents 1

HCID 21255859Isopropanol methanolSolvent

Procedure

A suspension of 50 g gluconolactone in 500 ml of isopropanol/methanol (4/1) was treated with 23.8 ml of a 40% N-methylamine solution for 30 minutes. The N-methylgluconamide obtained in quantitative yields, was treated at 60° C. with 69 ml acetic anhydride and 35 ml acetic acid in the presence of 1% concentrated sulphuric acid.

Sources & evidence

ORD record
ord-37ece4a4b5bd4990a6ee9924cd3108bc
Source dataset
uspto-grants-1995_03
Patent number
US05401435

Reaction notes

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