Tetrahydrofuran → N-[17-[2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methyl-quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide
Reaction equation
[C:47]([c:48]1[nH:49][cH:50][cH:51][n:52]1)([c:53]1[nH:54][cH:55][cH:56][n:57]1)=[O:58].[CH2:66]1[CH2:67][CH2:68][C:69]2=[N:74][CH2:73][CH2:72][CH2:71][N:70]2[CH2:75][CH2:76]1.[CH2:77]1[O:78][CH2:79][CH2:80][CH2:81]1.[CH:1]([CH3:2])([CH3:3])[c:4]1[n:5][c:6](-[c:9]2[n:10][c:11]3[c:12]([CH3:46])[c:13]([O:44][CH3:45])[cH:14][cH:15][c:16]3[c:17]([O:19][CH:20]3[CH2:21][CH:22]4[C:23](=[O:43])[N:24]([CH3:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH:29]=[CH:30][CH:31]5[CH2:32][C:33]5([C:39](=[O:40])[OH:41])[NH:34][C:35](=[O:38])[CH:36]4[CH2:37]3)[cH:18]2)[s:7][cH:8]1.[CH:59]1([S:62](=[O:63])(=[O:64])[NH2:65])[CH2:60][CH2:61]1>>[CH:1]([CH3:2])([CH3:3])[c:4]1[n:5][c:6](-[c:9]2[n:10][c:11]3[c:12]([CH3:46])[c:13]([O:44][CH3:45])[cH:14][cH:15][c:16]3[c:17]([O:19][CH:20]3[CH2:21][CH:22]4[C:23](=[O:43])[N:24]([CH3:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH:29]=[CH:30][CH:31]5[CH2:32][C:33]5([C:39](=[O:40])[NH:65][S:62]([CH:59]5[CH2:60][CH2:61]5)(=[O:63])=[O:64])[NH:34][C:35](=[O:38])[CH:36]4[CH2:37]3)[cH:18]2)[s:7][cH:8]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-e54a2ab89776405090fbc25e2f8337d8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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