2,3-dihydro-6-methoxy-2-(3-pyridylmethyl)-1H-isoindole-1-one → 2,3-dihydro-6-hydroxy-2-(3-pyridylmethyl)-1H-isoindole-1-one

HRID 1609598Notes

Reaction equation

HRID 1609598 reaction equation
C[O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][N:8]([CH2:13][C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)[C:9]2=[O:12])=[CH:5][CH:4]=1>Br>[OH:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][N:8]([CH2:13][C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)[C:9]2=[O:12])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 200820092,3-dihydro-6-methoxy-2-(3-pyridylmethyl)-1H-isoindole-1-one

Product 1

HCID 200819992,3-dihydro-6-hydroxy-2-(3-pyridylmethyl)-1H-isoindole-1-one

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

The titled compound was prepared in the same manner as in Example 10 (1) b) by refluxing 2,3-dihydro-6-methoxy-2-(3-pyridylmethyl)-1H-isoindole-1-one in 47% hydrogen bromide under heating.

Workup

  1. temperatureunder heating

Sources & evidence

ORD record
ord-a32ac53f504a4e81ad47c98644cc799a
Source dataset
uspto-grants-1995_03
Patent number
US05401756

Reaction notes

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