Tetrahydrofuran → 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone

HRID 1609647노트

반응식

HRID 1609647 반응식
Cl[CH2:2][C:3]1[CH2:8][C:7](=[O:9])[C:6]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][N:4]=1.O1CCCC1.Cl.[CH3:24][NH:25][CH3:26].[OH-].[Na+]>O>[CH2:11]([O:10][C:6]1[C:7](=[O:9])[CH2:8][C:3]([CH2:2][N:25]([CH3:26])[CH3:24])=[N:4][CH:5]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 10473Dimethylamine, hydrochlorideHCID 14798Sodium HydroxideHCID 677480612-Chloromethyl-5-benzyloxy-4-pyridone

생성물 1

HCID 677480495-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone수율 96.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 2-chloromethyl-5-benzyloxy-4-pyridone (1.0 g) , tetrahydrofuran (10 ml) and water (10 ml) were added dimethylamine hydrochloride (1.31 g) and sodium hydroxide (0.64 g) . After being stirred for 1.5 hours, the mixture was concentrated under reduced pressure to dryness. The residue was dissolved in methanol and the insoluble material was filtered off. The filtrate was evaporated in vacuo to give 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone (1.0 g) as a powder.

후처리

  1. concentrationthe mixture was concentrated under reduced pressure to dryness
  2. dissolutionThe residue was dissolved in methanol
  3. filtrationthe insoluble material was filtered off
  4. customThe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-3d413a960da2449e9e9125e3e9c35e0e
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05401734

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