反应详情

温度

180 °C

To a solution of 1.0 g of 3-bromo-6-nitro-1H-indazole in 10 ml N-methylpyrrolidone were added 2.0 g of (3-fluorophenyl)tri-n-butyltin, and 480 mg of tetrakis(triphenylphosphine)palladium(0), and the mixture was stirred at 180° C. for 2 hours. To the reaction mixture was added 60 ml of ethyl acetate. The mixture was sequentially washed with water (×2) and brine, dried over anhydrous magnesium sulfate and the solvent was evaporated. The crude product was purified and separated by silica gel column chromatography (ethyl acetate:toluene=1:49), to give 302 mg of the title compound as orange crystals.

1. washThe mixture was sequentially washed with water (×2) and brine
2. dry with materialdried over anhydrous magnesium sulfate
3. customthe solvent was evaporated
4. customThe crude product was purified
5. customseparated by silica gel column chromatography (ethyl acetate:toluene=1:49)