Propiolic Acid → HCID 22258164, compound

HRID 1610847Notes

Reaction equation

HRID 1610847 reaction equation
[Br:1][C:2]1[N:3]=[C:4]([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[O:9])[NH:5][CH:6]=1.[C:17](O)(=[O:20])[C:18]#[CH:19].N1(C(N2C=CN=C2)=O)C=CN=C1>>[Br:1][C:2]1[NH:3][C:4]2[N:5]([CH:6]=1)[C:17](=[O:20])[CH:18]=[CH:19][C:7]=2[C:8](=[O:9])[C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1

Participants

4

Reactant 3

HCID 10110Propiolic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 178520384HCID 178520384, compound

Product 1

HCID 22258164HCID 22258164, compound

Procedure

The compound is prepared as described in example 6 with 446.0 mg (1.58 mmol) of 2-(4-bromo-1H-imidazol-2-yl)-1-(4-fluorophenyl)ethanone (example XXXII), 172.43 mg (2.36 mmol) of propiolic acid and 459.82 mg (2.84 mmol) of 1-(1H-imidazol-1-ylcarbonyl)-1H-imidazole.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-4f660e7566b440789e013ad1c531e61d
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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