Propiolic Acid → HCID 22258272, compound

HRID 1610853Notes

Reaction equation

HRID 1610853 reaction equation
[CH3:1][CH:2]1[CH:20]([CH3:21])[CH2:19][C:5]2[NH:6][C:7]([CH2:9][C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)=[O:11])=[N:8][C:4]=2[CH2:3]1.[C:22](O)(=[O:25])[C:23]#[CH:24].N1(C(N2C=CN=C2)=O)C=CN=C1>>[F:18][C:15]1[CH:14]=[CH:13][C:12]([C:10]([C:9]2[CH:24]=[CH:23][C:22](=[O:25])[N:6]3[C:5]4[CH2:19][CH:20]([CH3:21])[CH:2]([CH3:1])[CH2:3][C:4]=4[NH:8][C:7]=23)=[O:11])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 10110Propiolic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 22258258HCID 22258258, compound

Product 1

HCID 22258272HCID 22258272, compound

Procedure

The compounds are prepared as described in example 10 with 200 mg (0.70 mmol) of 2-(5,6-Dimethyl-4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)-1-(4-fluorophenyl)ethanone (example XIV), 73.3 mg (1.05 mmol) of propiolic acid and 204 mg (1.26 mmol) of 1-(1H-imidazol-1-ylcarbonyl)-1H-imidazole.

Workup

  1. customThe compounds are prepared

Sources & evidence

ORD record
ord-6e2be6ba9a34476399ee578377b5d8cb
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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