Propiolic Acid → HCID 22258296, compound

HRID 1610855Notes

Reaction equation

HRID 1610855 reaction equation
[CH2:1]([C:5]1[N:6]=[C:7]([CH2:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])=[O:13])[NH:8][C:9]=1[CH3:10])[CH2:2][CH2:3][CH3:4].[C:22](O)(=[O:25])[C:23]#[CH:24].N1(C(N2C=CN=C2)=O)C=CN=C1>>[CH2:1]([C:5]1[NH:6][C:7]2[N:8]([C:9]=1[CH3:10])[C:22](=[O:25])[CH:23]=[CH:24][C:11]=2[C:12](=[O:13])[C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 10110Propiolic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 22258310HCID 22258310, compound

Product 1

HCID 22258296HCID 22258296, compound

Procedure

The compounds are prepared as described in example 10 with 200 mg (0.68 mmol) of 2-(4-Butyl-5-methyl-1H-imidazol-2-yl)-1-(2,4-difluorophenyl)ethanone (example XXI), 72 mg (1.03 mmol) of propiolic acid and 200 mg (1.23 mmol) of 1-(1H-imidazol-1yl-carbonyl)-1H-imidazole. The following compounds are obtained:

Workup

  1. customThe compounds are prepared
  2. customThe following compounds are obtained

Sources & evidence

ORD record
ord-4c93bf48195a435d87453fab7df760cf
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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