Propiolic Acid → HCID 22258273, compound

HRID 1610857Notes

Reaction equation

HRID 1610857 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:18])[CH2:9][C:10]2[NH:11][CH:12]=[C:13]([CH:15]([CH3:17])[CH3:16])[N:14]=2)=[CH:4][CH:3]=1.[C:19](O)(=[O:22])[C:20]#[CH:21].N1(C(N2C=CN=C2)=O)C=CN=C1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:9]2[CH:21]=[CH:20][C:19](=[O:22])[N:11]3[CH:12]=[C:13]([CH:15]([CH3:16])[CH3:17])[NH:14][C:10]=23)=[O:18])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 10110Propiolic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 178439624HCID 178439624, compound

Product 1

HCID 22258273HCID 22258273, compound

Procedure

The compound is prepared as described in example 10 with 65 mg (0.26 mmol) of 1-(4-fluorophenyl)-2-(4-isopropyl-1H-imidazol-2-yl)ethanone (example XXX), 27.7 mg (0.40 mmol) of propiolic acid and 77 mg (0.48 mmol) of 1-(1H-imidazol-1-yl-carbonyl)-1H-imidazole.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-df6a3410db8d4776b0b66e6fc9cc357d
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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