Sodium hydride → HCID 22259359, compound

HRID 1610986Notes

Reaction equation

HRID 1610986 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[O:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=2)=[CH:4][C:3]=1[F:17].[CH3:18][S:19]([CH2:22][C:23]1[N:24]([CH2:28][CH2:29][CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=2)[CH:25]=[CH:26][N:27]=1)(=[O:21])=[O:20].[H-].[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[O:11][CH:12]=[C:13]([CH2:15][O:38][C:35]3[CH:34]=[CH:33][C:32]([CH2:31][CH2:30][CH2:29][CH2:28][N:24]4[CH:25]=[CH:26][N:27]=[C:23]4[CH2:22][S:19]([CH3:18])(=[O:21])=[O:20])=[CH:37][CH:36]=3)[N:14]=2)=[CH:4][C:3]=1[F:17]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 222592974-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenolHCID 22259331HCID 22259331, compound

Product 1

HCID 22259359HCID 22259359, compoundYield 62.9%

Procedure

Using 2-[(E)-2-(4-chloro-3-fluorophenyl)ethenyl]-4-(chloromethyl)-1,3-oxazole (291 mg), 4-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol (300 mg) and 65% sodium hydride (39.5 mg), the same reaction as Example 11-(i) was carried out to yield the titled compound (333 mg) as colorless needle crystals.

Workup

  1. customthe same reaction as Example 11-(i)

Sources & evidence

ORD record
ord-62e87ed2d48748cfbdaad8be86f87b94
Source dataset
uspto-grants-2006_01
Patent number
US06984653B2

Reaction notes

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