2-Propanesulfonyl chloride → HCID 22259307, compound

HRID 1610989Notes

Reaction equation

HRID 1610989 reaction equation
[F:1][C:2]([F:37])([F:36])[C:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]2[O:12][CH:13]=[C:14]([CH2:16][O:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][CH2:26][CH2:27][N:28]4[CH:32]=[CH:31][N:30]=[C:29]4[CH2:33][CH2:34][NH2:35])=[CH:20][CH:19]=3)[N:15]=2)=[CH:5][CH:4]=1.[CH3:38][CH:39]([S:41](Cl)(=[O:43])=[O:42])[CH3:40]>C(N(CC)CC)C>[F:37][C:2]([F:36])([F:1])[C:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]2[O:12][CH:13]=[C:14]([CH2:16][O:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][CH2:26][CH2:27][N:28]4[CH:32]=[CH:31][N:30]=[C:29]4[CH2:33][CH2:34][NH:35][S:41]([CH:39]([CH3:40])[CH3:38])(=[O:43])=[O:42])=[CH:20][CH:19]=3)[N:15]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 22259339HCID 22259339, compound

Product 1

HCID 22259307HCID 22259307, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Using 2-[1-[4-[4-[[2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazol-4-yl]methoxy]phenyl]butyl]-1H-imidazol-2-yl]ethylamine (248 mg), triethylamine (135 μl) and 2-propanesulfonyl chloride (65.5 μl), the same reaction as Example 31 was carried out to yield the titled compound (55 mg) as colorless needle crystals.

Workup

  1. customthe same reaction as Example 31

Sources & evidence

ORD record
ord-23312ace0e8a4ed0aa331ce4108f5528
Source dataset
uspto-grants-2006_01
Patent number
US06984653B2

Reaction notes

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