HCID 23591244, compound → HCID 86599715, compound

HRID 1611076Notes

Reaction equation

HRID 1611076 reaction equation
[ClH:1].[CH3:2][C@@H:3]([NH:9][CH2:10][CH2:11][P:12]([O:17]CC)(=[O:16])[O:13]CC)[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]>Cl>[ClH:1].[CH3:2][C@@H:3]([NH:9][CH2:10][CH2:11][P:12]([OH:17])(=[O:13])[OH:16])[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 1

HCID 23591244HCID 23591244, compound

Product 1

HCID 86599715HCID 86599715, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of (R)-diethyl 2-(2-heptylamino)ethanephosphonate hydrochloride (0.19 g, 0.68 mmol) in concentrated HCl (7 mL) was heated at 90° C. for 48 hours. The reaction mixture was then evaporated to dryness and the residue triturated with acetone. The white solid was filtered and air-dried giving an 86% overall yield; m.p.=106-112° C. (no lit. value).

Workup

  1. customThe reaction mixture was then evaporated to dryness
  2. customthe residue triturated with acetone
  3. filtrationThe white solid was filtered
  4. customair-dried
  5. customgiving an 86% overall yield

Sources & evidence

ORD record
ord-059630d150e245a584289ad55c1cb835
Source dataset
uspto-grants-2006_01
Patent number
US06984754B1

Reaction notes

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