Potassium Carbonate → HCID 15289174, compound

HRID 1611434Notes

Reaction equation

HRID 1611434 reaction equation
[NH2:1][C:2]1[C:3]2[C:10]([C:11]#[C:12][Si](C)(C)C)=[CH:9][N:8]([C@@H:17]3[O:22][C@H:21]([CH2:23][OH:24])[C@@H:19]([OH:20])[CH2:18]3)[C:4]=2[N:5]=[CH:6][N:7]=1.C([O-])([O-])=O.[K+].[K+]>CO>[NH2:1][C:2]1[C:3]2[C:10]([C:11]#[CH:12])=[CH:9][N:8]([C@@H:17]3[O:22][C@H:21]([CH2:23][OH:24])[C@@H:19]([OH:20])[CH2:18]3)[C:4]=2[N:5]=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 15289172HCID 15289172, compound

Product 1

HCID 15289174HCID 15289174, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

200 mg of compound (23) are dissolved in 20 ml of MeOH. Adding 8 mg of K2CO3 results in hydrolysis after 1 h of stirring. After the solution has been subjected to rotary evaporation, the residue is chromatographed on silica gel in the eluent methylene chloride/MeOH (8:1). Recrystallization from MeOH results in colorless crystals (73%).

Workup

  1. customresults in hydrolysis after 1 h
  2. customAfter the solution has been subjected to rotary evaporation
  3. customthe residue is chromatographed on silica gel in the eluent methylene chloride/MeOH (8:1)
  4. customRecrystallization from MeOH

Sources & evidence

ORD record
ord-6832528897e14d89ac28cf9f22f6a56f
Source dataset
uspto-grants-2006_01
Patent number
US06987177B2

Reaction notes

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