Diisopropylethylamine → HCID 23591845, compound

HRID 1611710Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13](F)[CH:12]=[CH:11][C:10]=1[N+:16]([O-:18])=[O:17].[NH2:19][C:20]1[N:25]=[C:24]([NH:26][CH2:27][CH2:28][NH:29][CH3:30])[CH:23]=[CH:22][C:21]=1[N+:31]([O-:33])=[O:32].C(N(CC)C(C)C)(C)C>C(#N)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:10]([N+:16]([O-:18])=[O:17])=[CH:11][CH:12]=[C:13]([N:29]([CH3:30])[CH2:28][CH2:27][NH:26][C:24]2[N:25]=[C:20]([NH2:19])[C:21]([N+:31]([O-:33])=[O:32])=[CH:22][CH:23]=2)[CH:14]=1

Participants

Conditions

Temperature: 85 °C

Procedure

To 10 mgs of 2-(2,4-dichlorophenyl)-4-fluoro-1-nitrobenzene in acetonitrile was added 10 mgs of (6-amino-5-nitro(2-pyridyl))[2-(methylamino)ethyl]amine and 7 μl of N,N-diisopropylethylamine, and the mixture was heated to 85° C. over-night. After an aqueous work up the crude was purified on a silica gel column with 30% acetone in hexane as the eluent to give 6 mgs of N˜6˜-{2-[(2′,4′-dichloro-6-nitro-1,1′-biphenyl-3-yl)(methyl)amino]ethyl}-3-nitropyridine-2,6-diamine.

Workup

customAfter an aqueous work up the crude was purified on a silica gel column with 30% acetone in hexane as the eluent

Sources & evidence

ORD record: ord-555d4520460d428d84ae99e478ed5687
Source dataset: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06989382B2

Reaction notes

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