反应详情

A mixture of 2-(6-nitro-5-ethoxy-pyridin-3-yl)-2-hydroxy-propionic acid ethyl ester (1.3 g), ammonium formate (1.5 g), and 10% Pd/C (100 mg) was stirred in a 1:1 mixture of THF/methanol overnight. The reaction mixture was filtered through diatomaceous earth, and the filtrate evaporated to yield an oil. The oil was dissolved in EtOAc, washed with water and brine, and the organic layer separated and dried over magnesium sulfate. Evaporation furnished 863 mg of the title compound. LC/MS+=255.

1. filtrationThe reaction mixture was filtered through diatomaceous earth
2. customthe filtrate evaporated
3. customto yield an oil
4. washwashed with water and brine
5. customthe organic layer separated
6. dry with materialdried over magnesium sulfate
7. customEvaporation