Potassium Carbonate → HCID 22252715, compound

HRID 1612028Notes

Reaction equation

HRID 1612028 reaction equation
[OH:1][C:2]1[C:3]([Se:16][C:17]2[CH:27]=[CH:26][C:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:19][CH:18]=2)=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.[C:28]([O:31][CH2:32][CH2:33]Br)(=[O:30])[CH3:29].C(=O)([O-])[O-].[K+].[K+]>CCC(C)=O>[C:28]([O:31][CH2:32][CH2:33][O:1][C:2]1[C:3]([Se:16][C:17]2[CH:27]=[CH:26][C:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:19][CH:18]=2)=[CH:4][C:5]2[C:6]([CH3:14])([CH3:15])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1)(=[O:30])[CH3:29]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 135641-Acetoxy-2-bromoethaneHCID 22252718HCID 22252718, compound

Product 1

HCID 22252715HCID 22252715, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

In a manner similar to that of Example 51, by reaction of 400 mg (0.93 mmol) of ethyl 4-(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanyl)benzoate with 334 mg (2.2 mmol) of 2-bromoethyl acetate and 257 mg of potassium carbonate in MEK (10 ml), 333 mg (69%) of a yellow oil are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-1555ba334be94ed596a8ce2ad50c723d
Source dataset
uspto-grants-2006_01
Patent number
US06992094B1

Reaction notes

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