Toluene → HCID 86602661, compound

HRID 1612031Notes

Reaction equation

HRID 1612031 reaction equation
[CH3:1][C:2]1[C:3]([Se:16][C:17]2[CH:25]=[CH:24][C:20]([C:21](O)=O)=[CH:19][N:18]=2)=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.C1(C)C=CC=CC=1.S(Cl)([Cl:35])=O>CN(C=O)C>[CH3:1][C:2]1[C:3]([Se:16][C:17]2[CH:25]=[CH:24][C:20]([CH2:21][Cl:35])=[CH:19][N:18]=2)=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1

Participants

5

Reactant 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 9844045HCID 9844045, compound

Product 1

HCID 86602661HCID 86602661, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2 g (5 mmol) of 6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanyl)nicotinic acid, 20 ml of toluene, 100 μl of DMF and 450 μl of thionyl chloride are introduced into a round-bottomed flask. The reaction medium is refluxed for one hour and evaporated. 100% of the expected acid chloride are collected, this product being used for the rest of the synthesis without further purification.

Workup

  1. temperatureThe reaction medium is refluxed for one hour
  2. customevaporated
  3. custom100% of the expected acid chloride are collected
  4. customthis product being used for the rest of the synthesis without further purification

Sources & evidence

ORD record
ord-efe05f2fd0f84056abb5b2be851fed61
Source dataset
uspto-grants-2006_01
Patent number
US06992094B1

Reaction notes

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