Ethyl [(7-{[2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetate--hydrogen chloride (1/1) → 121524-08-1

HRID 1612396Notes

Reaction equation

HRID 1612396 reaction equation
[CH3:1][CH2:2][O:3][C:4]([CH2:6][O:7][C:8]1[CH:28]=[CH:27][C:11]2[CH2:12][CH2:13][C@H:14]([NH:16][CH2:17][C@H:18]([OH:26])[C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=3)[CH2:15][C:10]=2[CH:9]=1)=[O:5].Cl>CC(O)C>[CH3:1][CH2:2][O:3][C:4]([CH2:6][O:7][C:8]1[CH:28]=[CH:27][C:11]2[CH2:12][CH2:13][C@H:14]([NH:16][CH2:17][C@H:18]([OH:26])[C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=3)[CH2:15][C:10]=2[CH:9]=1)=[O:5]

Participants

3

Reactant 1

HCID 121888Ethyl [(7-{[2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetate--hydrogen chloride (1/1)2×

Product 1

HCID 3035442121524-08-1

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Polymorphic SR58611 hydrochloride (95.2 g) is suspended at 70° C. in 0.3 liter of propan-2-ol. After maintaining for 12 h 30 under isothermal conditions, the suspension is composed of SR58611 hydrochloride, B form, >98%. IR spectrum and X-ray diffraction are in agreement.

Workup

  1. temperatureAfter maintaining for 12 h 30 under isothermal conditions

Sources & evidence

ORD record
ord-2f7a7d02f4604c47893eb6d2d6db0ecf
Source dataset
uspto-grants-2006_01
Patent number
US06992211B2

Reaction notes

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