Trityl chloride → HCID 54541069, compound

HRID 1612622Notes

Reaction equation

HRID 1612622 reaction equation
[C@@H:1]1([N:9]2[CH:16]=[CH:15][C:13](=[O:14])[NH:12][C:10]2=[O:11])[O:8][C@H:5]([CH2:6][OH:7])[C@@H:3]([OH:4])[CH2:2]1.[C:17](Cl)([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>N1C=CC=CC=1>[C:17]([CH:6]([OH:7])[C@H:5]1[O:8][C@@H:1]([N:9]2[CH:16]=[CH:15][C:13](=[O:14])[NH:12][C:10]2=[O:11])[CH2:2][C@@H:3]1[OH:4])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 6456Trityl chlorideHCID 13712Deoxyuridine

Product 1

HCID 54541069HCID 54541069, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2'-deoxyuridine (11.4 g, 0.05 mole) and trityl chloride (13.95 g, 0.05 mole) in dry pyridine 55 ml) was heated at 100° C. for 40 min. After cooling, the mixture was poured into an ice-water mixture (1 l), the precipitate filtered, washed with water, dissolved in chloroform, dried (MgSO4), and then evaporated to a syrup (20.5 g, 85%).

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitate filtered
  3. washwashed with water
  4. dissolutiondissolved in chloroform
  5. dry with materialdried (MgSO4)
  6. customevaporated to a syrup (20.5 g, 85%)

Sources & evidence

ORD record
ord-5c264e2e7bce46aeaece24e5c98c4d5b
Source dataset
uspto-grants-1993_03
Patent number
US05190926

Reaction notes

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