HCID 54303576, compound → HCID 54183520, compound

HRID 1612647Notes

Reaction equation

HRID 1612647 reaction equation
[CH2:1]([O:3][C:4](=[S:19])[C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[C:7]([N+:14]([O-])=O)[C:6]=1[CH2:17][CH3:18])[CH3:2]>O1CCCC1.[Ni].C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[S:19])[C:5]1[CH:10]=[C:9]([NH2:11])[CH:8]=[C:7]([NH2:14])[C:6]=1[CH2:17][CH3:18])[CH3:2]

Participants

5

Reactant 1

HCID 54303576HCID 54303576, compound

Product 1

HCID 54183520HCID 54183520, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

25.9 g (0.0862 mol) of 3,5-dinitro-2-ethylthiobenzoic acid ethyl ester are dissolved in 260 ml of tetrahydrofuran and hydrogenated at 30°-35° C. in the presence of 10 g of Raney nickel. The catalyst is then isolated by filtration, and the residue is taken up in ethyl acetate, dried over magnesium sulfate, filtered and concentrated.

Workup

  1. customThe catalyst is then isolated by filtration
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-6276c9506dbe4bccba735fef527268ea
Source dataset
uspto-grants-1993_03
Patent number
US05190928

Reaction notes

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