Hydrochloric Acid → HCID 10037816, compound

HRID 1612708Notes

Reaction equation

HRID 1612708 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:10]([F:15])([F:14])[CH2:11][CH2:12][CH3:13])(=[O:9])[O:6]CC.[ClH:16]>>[ClH:16].[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:10]([F:15])([F:14])[CH2:11][CH2:12][CH3:13])(=[O:6])[OH:9]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 10263800HCID 10263800, compound

Product 1

HCID 10037816HCID 10037816, compound

Conditions

Temperature
80 °C

Procedure

A mixture of 1.4 g (5.8 mMol) of ethyl 3-aminopropyl(1,1-difluorobutyl)phosphinate and 15 ml of 12M hydrochloric acid is stirred for 8 hours at 80° C. The reaction mixture is evaporated to dryness and the residue is recrystallized from ethanol/ether giving 3-aminopropyl-(1,1-difluorobutyl)phosphinic acid hydrochloride, m.p. 149°-151° C.

Workup

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue is recrystallized from ethanol/ether

Sources & evidence

ORD record
ord-bd21b70a71614d6a925863cc8fd087b5
Source dataset
uspto-grants-1993_03
Patent number
US05190933

Reaction notes

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