反应详情

温度

-50 °C

A solution of n-butyl lithium in hexane (2.5 M, 178 ml, 0.444 mol) was added dropwise to a mechanically stirred solution of hexahydroazepin-2-one (22.8 g, 0.202 mol) in tetrahydrofuran (400 ml) over a period of 90 minutes at 0° C. The solution was stirred for 3 hours and then cooled to -50° C. Benzyl bromide (24 ml, 0.202 mol) in tetrahydrofuran (100 ml) was then added dropwise over a period of 1 hour and the reaction mixture allowed to warm slowly to room temperature and stirred for 15 hours. Addition of water (100 ml) and saturated aqueous ammonium chloride (100 ml) was followed by extraction of the aqueous phase with ethyl acetate (3×100 ml). The combined organic phases were washed with brine, dried with sodium sulphate and evaporated in vacuo. Flash column chromatography upon silica gel of the resulting oily solid using ethyl acetate: methanol (25:1) as eluant afforded a solid which was recrystallised from benzene/hexanes to give the desired product as an off white solid, 10.3 g, M.pt. 99°-104° C., M+ found: 203.

1. temperatureto warm slowly to room temperature
2. stirringstirred for 15 hours
3. extractionwas followed by extraction of the aqueous phase with ethyl acetate (3×100 ml)
4. washThe combined organic phases were washed with brine
5. dry with materialdried with sodium sulphate
6. customevaporated in vacuo
7. customafforded a solid which
8. customwas recrystallised from benzene/hexanes