Benzyl Bromide → HCID 15406763, compound

HRID 1612755Notes

Reaction equation

HRID 1612755 reaction equation
C([Li])CCC.CCCCCC.[NH:12]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][C:13]1=[O:19].[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[Cl-].[NH4+]>O1CCCC1.O>[C:21]1([CH2:20][CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][NH:12][C:13]2=[O:19])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

8

Reactant 5

HCID 7498Benzyl BromideHCID 7768CaprolactamHCID 8058HexaneHCID 25517Ammonium ChlorideHCID 178418339Butyllithium

Product 1

HCID 15406763HCID 15406763, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
-50 °C

Procedure

A solution of n-butyl lithium in hexane (2.5 M, 178 ml, 0.444 mol) was added dropwise to a mechanically stirred solution of hexahydroazepin-2-one (22.8 g, 0.202 mol) in tetrahydrofuran (400 ml) over a period of 90 minutes at 0° C. The solution was stirred for 3 hours and then cooled to -50° C. Benzyl bromide (24 ml, 0.202 mol) in tetrahydrofuran (100 ml) was then added dropwise over a period of 1 hour and the reaction mixture allowed to warm slowly to room temperature and stirred for 15 hours. Addition of water (100 ml) and saturated aqueous ammonium chloride (100 ml) was followed by extraction of the aqueous phase with ethyl acetate (3×100 ml). The combined organic phases were washed with brine, dried with sodium sulphate and evaporated in vacuo. Flash column chromatography upon silica gel of the resulting oily solid using ethyl acetate: methanol (25:1) as eluant afforded a solid which was recrystallised from benzene/hexanes to give the desired product as an off white solid, 10.3 g, M.pt. 99°-104° C., M+ found: 203.

Workup

  1. temperatureto warm slowly to room temperature
  2. stirringstirred for 15 hours
  3. extractionwas followed by extraction of the aqueous phase with ethyl acetate (3×100 ml)
  4. washThe combined organic phases were washed with brine
  5. dry with materialdried with sodium sulphate
  6. customevaporated in vacuo
  7. customafforded a solid which
  8. customwas recrystallised from benzene/hexanes

Sources & evidence

ORD record
ord-9756290583164f59bae221937923174b
Source dataset
uspto-grants-1993_03
Patent number
US05190958

Reaction notes

Loading…