反应详情

Methyl (-)-(2-aminoindan-5-yl)acetate.(-)-dibenzoyl-L-tartaric acid salt (3.94 g) is added to a mixture of potassium carbonate (4.83 g), water (50 ml) and ethyl acetate (70 ml), and 4-chlorophenylsulfonyl chloride (1.49 g) is added thereto. The mixture is stirred at room temperature for one hour. The ethyl acetate layer is separated from the reaction mixture, washed with an aqueous sodium hydrogen carbonate solution, dried, and distilled under reduced pressure to remove the solvent. The residue is recrystallized from a mixture of ethyl acetate and hexane to give methyl (-)-[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetate (2.43 g) as colorless crystals.

1. additionis added
2. customThe ethyl acetate layer is separated from the reaction mixture
3. washwashed with an aqueous sodium hydrogen carbonate solution
4. customdried
5. distillationdistilled under reduced pressure
6. customto remove the solvent
7. customThe residue is recrystallized from a mixture of ethyl acetate and hexane