Ammonium → tert-butyl 4-(5-cyclopropyl-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate
Reaction equation
[Br-:1].[Br:6][c:7]1[c:8]([N:25]2[CH2:26][CH2:27][N:28]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:29][CH2:30]2)[c:9]2[c:10]([n:11][cH:12]1)[n:13]([CH2:16][c:17]1[cH:18][cH:19][c:20]([O:23][CH3:24])[cH:21][cH:22]1)[n:14][cH:15]2.[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH:2]1([Zn+:5])[CH2:3][CH2:4]1.[Cl-:38].[NH4+:39].[cH:45]1[cH:46][cH:47][c:48]([P:49]([Pd:50]([P:51]([c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)([c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)[c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)([P:70]([c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)([c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)[c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)[P:89]([c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)([c:96]2[cH:97][cH:98][cH:99][cH:100][cH:101]2)[c:102]2[cH:103][cH:104][cH:105][cH:106][cH:107]2)([c:108]2[cH:109][cH:110][cH:111][cH:112][cH:113]2)[c:114]2[cH:115][cH:116][cH:117][cH:118][cH:119]2)[cH:120][cH:121]1>>[CH:2]1([c:7]2[c:8]([N:25]3[CH2:26][CH2:27][N:28]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:29][CH2:30]3)[c:9]3[c:10]([n:11][cH:12]2)[n:13]([CH2:16][c:17]2[cH:18][cH:19][c:20]([O:23][CH3:24])[cH:21][cH:22]2)[n:14][cH:15]3)[CH2:3][CH2:4]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-3617a223e1274dc1b1a1747c721a77d4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
Loading…