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HRID1612940

反应详情

EQUATION

反应方程式

HRID 1612940 的结构方程式

REACTANTS

反应物

5
结构：N
HCID222

Ammonia gas

H3N

结构：[Cl-]
HCID312

Chloride

Cl-

结构：CC(C)Cc1ccc([C@H](C)C(=O)O)cc1
HCID39912

Dexibuprofen

C13H18O2

结构：O=C(Cl)C(=O)Cl
HCID65578

Ethanedioyl dichloride

C2Cl2O2

结构：CC(C)Cc1ccc([C@H](C)C(=O)Cl)cc1
HCID10609225

(αS)-α-Methyl-4-(2-methylpropyl)benzeneacetyl chloride

C13H17ClO

PRODUCTS

生成物

1
结构：CC(C)Cc1ccc([C@H](C)C(N)=O)cc1
HCID715796

(αS)-α-Methyl-4-(2-methylpropyl)benzeneacetamide

C13H19NO

PROCEDURE

实验过程

The above hydrolysis procedure gives about 2% racemization demonstrated by: (1) converting a sample of (S)-(+)-ibuprofen (98.6% S enantiomer by HPLC) to (S)-(+)-2-(4-isobutylphenyl)propanoyl chloride with oxalyl chloride; (2) treating the chloride with ammonia to obtain (S)-(+)-2-(4-isobutylphenyl)propionamide; and (3) hydrolyzing the amide as described above to regenerate (S)-(+)-ibuprofen (96.6% S enantiomer by HPLC).

WORKUP

后处理

  1. customThe above hydrolysis procedure
  2. customgives about 2% racemization