HRID1613066

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID88068

Methyl 3-hydroxybenzoate

C8H8O3

结构：ICCCCCCc1cccc(OCc2ccccc2)c1OCc1ccccc1

HCID14986285

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1cccc(OCCCCCCc2cccc(OCc3ccccc3)c2OCc2ccccc2)c1

HCID14986346

未命名化合物

收率 66%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture of 0.58 g of 1-(6-iodohexyl)-2,3-bis (phenylmethoxy)benzene, 0.18 g of 3-hydroxybenzoic acid methyl ester and 0.25 g of potassium carbonate in 15 mL of acetone was stirred at reflux for 18 hours. Workup as in Example 16 and purification by HPLC using toluene gave 0.40 g (66% yield) of 3-[6-[2,3-bis(phenylmethoxy)phenyl]hexyloxy]benzoic acid methyl ester as an oil.

WORKUP

后处理

temperatureat reflux for 18 hours
customWorkup as in Example 16 and purification by HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f3ae2a24b7e94cc19dc719bf3c7d7361
来源数据集: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05191108
来源说明: uspto-grants-1993_03

反应 SMILES

I[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[CH3:30][O:31][C:32](=[O:40])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([OH:39])[CH:34]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:30][O:31][C:32](=[O:40])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([O:39][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:9]=2[O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:34]=1