Hydrochloric Acid → HCID 19775313, compound

HRID 1613178Notes

Reaction equation

HRID 1613178 reaction equation
[C:1]1([CH:7]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[O:8][CH2:9][C:10]([N:13]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22](OCC)=[O:23])=[CH:18][CH:17]=2)[CH3:14])([CH3:12])[CH3:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[ClH:39]>CCOCC>[ClH:39].[C:27]1([CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[O:8][CH2:9][C:10]([N:13]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([CH2:22][OH:23])=[CH:20][CH:21]=2)[CH3:14])([CH3:11])[CH3:12])[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 19775312HCID 19775312, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19775313HCID 19775313, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The free base of the title compound was prepared similarly to the procedure of Example 40 using 1-diphenylmethoxy-2-[N-(4-ethoxycarbonylbenzyl)-N- methylamino]-2-methylpropane (see Example 28) and lithium aluminium hydride. The resulting oil was dissolved in ether and the solution treated with an excess of saturated ethereal hydrogen chloride. The resulting precipitated oil was collected, washed with ether and dried to give the title compound as a colourless foam which was characterised as a hydrochloride containing 0.25 molar equivalents of water (377 mg, 38%).

Workup

  1. customThe resulting precipitated oil
  2. customwas collected
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-633d15f3076547ab85144ec2f59f97ab
Source dataset
uspto-grants-1993_03
Patent number
US05192765

Reaction notes

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