反应详情

A mixture of 2-amino-2-methylpropanol (89.1 g), benzhydrol (190 g) and para-toluenesulphonic acid monohydrate (200 g) in toluene (1200 ml) was heated under reflux in a Dean-Stark apparatus for four hours and evaporated. The residue was partitioned between ether and water and the organic layer was washed with water and extracted into 10% aqueous citric acid. The acidic extract was washed with ether, basified with solid sodium carbonate and extracted into ether. The organic extract was washed with water, dried over sodium sulphate and evaporated to give the title compound as a pale yellow oil (177 g, 69%) which was characterised by its 1H-n.m.r. spectrum.

1. temperaturewas heated
2. temperatureunder reflux in a Dean-Stark apparatus for four hours
3. customevaporated
4. customThe residue was partitioned between ether and water
5. washthe organic layer was washed with water
6. extractionextracted into 10% aqueous citric acid
7. extractionThe acidic extract
8. washwas washed with ether
9. extractionextracted into ether
10. extractionThe organic extract
11. washwas washed with water
12. dry with materialdried over sodium sulphate
13. customevaporated