Thioacetamide → HCID 19775566, compound

HRID 1613235Notes

Reaction equation

HRID 1613235 reaction equation
Cl[CH:2]([C:13](=O)[CH2:14][CH2:15][CH3:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1.[C:18]([NH2:21])(=[S:20])[CH3:19]>C(OCC)(=O)C>[CH3:19][C:18]1[S:20][C:2]([CH2:3][C:4]2[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=2)=[C:13]([CH2:14][CH2:15][CH3:16])[N:21]=1

Participants

4

Reactant 2

HCID 2723949ThioacetamideHCID 19775543HCID 19775543, compound

Product 1

HCID 19775566HCID 19775566, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 5.9 of 2-chloro-1-(4-nitrophenyl)hexan-3-one and 1.7 g of thioacetamide is heated at 90°-100° C. for 6 hours and then cooled and taken up with ethyl acetate. The precipitate formed is filtered off and washed with ethyl acetate and then with ether to give 5.6 g of 2-methyl-4-propyl-5-(4-nitrobenzyl)thiazole in the form of crystals melting at 124° C.

Workup

  1. temperatureis heated at 90°-100° C. for 6 hours
  2. temperaturecooled
  3. customThe precipitate formed
  4. filtrationis filtered off
  5. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-3e1147e8fe5b4d8db7257085361567d4
Source dataset
uspto-grants-1993_03
Patent number
US05192781

Reaction notes

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