反应详情

A mixture of 5.9 of 2-chloro-1-(4-nitrophenyl)hexan-3-one and 1.7 g of thioacetamide is heated at 90°-100° C. for 6 hours and then cooled and taken up with ethyl acetate. The precipitate formed is filtered off and washed with ethyl acetate and then with ether to give 5.6 g of 2-methyl-4-propyl-5-(4-nitrobenzyl)thiazole in the form of crystals melting at 124° C.

1. temperatureis heated at 90°-100° C. for 6 hours
2. temperaturecooled
3. customThe precipitate formed
4. filtrationis filtered off
5. washwashed with ethyl acetate