反应详情

A mixture of 1.2 g of methoxythioacetamide and 3 g of 2-chloro-1-(4-nitrophenyl)hexan-3-one is heated at 90°-100° C. for 4 hours and then cooled and taken up with ethyl acetate. The solution obtained is passed over animal charcoal and then evaporated. The brown oil obtained is purified on a silica column (eluent: 6/4 cyclohexane/ethyl acetate) to give 0.9 g of 2-methoxymethyl-4-propyl-5-(4-nitrobenzyl)thiazole in the form of a brown oil, which is used as such for the next step.

1. temperatureis heated at 90°-100° C. for 4 hours
2. temperaturecooled
3. customThe solution obtained
4. customevaporated
5. customThe brown oil obtained
6. customis purified on a silica column (eluent: 6/4 cyclohexane/ethyl acetate)