Hydrochloric Acid → HCID 19775639, compound

HRID 1613260Notes

Reaction equation

HRID 1613260 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:15][OH:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][S:22](Cl)(=[O:24])=[O:23].C(N(CC)CC)C.Cl>C1C=CC=CC=1>[CH3:21][S:22]([O:16][CH2:15][CH:14]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[O:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:17][CH2:18][CH2:19][CH3:20])(=[O:24])=[O:23]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 19775643HCID 19775643, compound

Product 1

HCID 19775639HCID 19775639, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Into a 500 ml round bottom flask are placed 15.6 g (0.06 mole) of 2-(o-phenoxyphenyl)hexan-1-ol, in 100 ml of benzene and 7.9 g. (0.07 mole) of methane sulfonyl chloride. To this mixture is added 8.2 g (0.08 mole) of triethyl amine dropwise at 10°. The reaction mixture is stirred overnight at room temperature and poured into 150 ml 10% hydrochloric acid. It is then extracted with benzene and the combined benzene extracts are washed with water and dried over Na2SO4. Solvent is evaporated to give 20 g of product.

Workup

  1. customInto a 500 ml round bottom flask are placed
  2. extractionIt is then extracted with benzene
  3. washthe combined benzene extracts are washed with water
  4. dry with materialdried over Na2SO4
  5. customSolvent is evaporated

Sources & evidence

ORD record
ord-e0146cb8a9394e26b06a9f07b6a8dac1
Source dataset
uspto-grants-1993_03
Patent number
US05192783

Reaction notes

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